Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation

Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding nucleotides and that SHM machinery generates biase...

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Detalles Bibliográficos
Autores principales: Sheng, Zizhang, Schramm, Chaim A., Kong, Rui, Mullikin, James C., Mascola, John R., Kwong, Peter D., Shapiro, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424261/
https://www.ncbi.nlm.nih.gov/pubmed/28539926
http://dx.doi.org/10.3389/fimmu.2017.00537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424261/
https://www.ncbi.nlm.nih.gov/pubmed/28539926
http://dx.doi.org/10.3389/fimmu.2017.00537

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