Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

BACKGROUND: In recent years, proinflammatory cytokine interleukin-1β (IL-1β) was considered to play a critical role in the pathogenesis of depression. In addition, P2X7 receptor (P2X7R), a member of the purinergic receptor family, which is predominantly present on microglia, as well as on astrocytes...

Descripción completa

Detalles Bibliográficos
Autores principales: Yue, Na, Huang, Huijie, Zhu, Xiaocang, Han, Qiuqin, Wang, Yalin, Li, Bing, Liu, Qiong, Wu, Gencheng, Zhang, Yuqiu, Yu, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424302/
https://www.ncbi.nlm.nih.gov/pubmed/28486969
http://dx.doi.org/10.1186/s12974-017-0865-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424302/
https://www.ncbi.nlm.nih.gov/pubmed/28486969
http://dx.doi.org/10.1186/s12974-017-0865-y

Ejemplares similares