A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis

BACKGROUND: Hypomethylation of the cathepsin Z locus has been proposed as an epigenetic risk factor for multiple sclerosis (MS). Cathepsin Z is a unique lysosomal cysteine cathepsin expressed primarily by antigen presenting cells. While cathepsin Z expression has been associated with neuroinflammato...

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Detalles Bibliográficos
Autores principales: Allan, Euan R. O., Campden, Rhiannon I., Ewanchuk, Benjamin W., Tailor, Pankaj, Balce, Dale R., McKenna, Neil T., Greene, Catherine J., Warren, Amy L., Reinheckel, Thomas, Yates, Robin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424360/
https://www.ncbi.nlm.nih.gov/pubmed/28486971
http://dx.doi.org/10.1186/s12974-017-0874-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424360/
https://www.ncbi.nlm.nih.gov/pubmed/28486971
http://dx.doi.org/10.1186/s12974-017-0874-x

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