Tumor-Selective Cytotoxicity of Nitidine Results from Its Rapid Accumulation into Mitochondria

We identified a nitidine- (NTD-) accumulating organelle and evaluated the net cytotoxicity of accumulated NTD. To evaluate tumor cell selectivity of the drug, we evaluated its selective cytotoxicity against 39 human cancer cell lines (JFCR39 panel), and the profile was compared with those of known a...

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Detalles Bibliográficos
Autores principales: Iwasaki, Hironori, Inafuku, Masashi, Taira, Naoyuki, Saito, Seikoh, Oku, Hirosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424480/
https://www.ncbi.nlm.nih.gov/pubmed/28529950
http://dx.doi.org/10.1155/2017/2130594

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424480/
https://www.ncbi.nlm.nih.gov/pubmed/28529950
http://dx.doi.org/10.1155/2017/2130594

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