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Integrase-Deficient Lentiviral Vector as an All-in-One Platform for Highly Efficient CRISPR/Cas9-Mediated Gene Editing

The CRISPR/Cas9 systems have revolutionized the field of genome editing by providing unprecedented control over gene sequences and gene expression in many species, including humans. Lentiviral vectors (LVs) are one of the primary delivery platforms for the CRISPR/Cas9 system due to their ability to...

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Detalles Bibliográficos
Autores principales: Ortinski, Pavel I., O’Donovan, Bernadette, Dong, Xiaoyu, Kantor, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424571/
https://www.ncbi.nlm.nih.gov/pubmed/28497073
http://dx.doi.org/10.1016/j.omtm.2017.04.002