Hepcidin links gluco-toxicity to pancreatic beta cell dysfunction by inhibiting Pdx-1 expression

OBJECTIVE: Gluco-toxicity is a term used to convey the detrimental effect of hyperglycemia on β-cell function through impaired insulin synthesis. Although it is known that the expression and activity of several key insulin transcription regulators is inhibited, other molecular mechanisms that mediat...

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Detalles Bibliográficos
Autores principales: Mao, Xuhua, Chen, Hucheng, Tang, Junmin, Wang, Liangliang, Shu, Tingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424768/
https://www.ncbi.nlm.nih.gov/pubmed/28179377
http://dx.doi.org/10.1530/EC-16-0115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424768/
https://www.ncbi.nlm.nih.gov/pubmed/28179377
http://dx.doi.org/10.1530/EC-16-0115

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