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Multiplexed Dynamic Imaging of Genomic Loci by Combined CRISPR Imaging and DNA Sequential FISH

Visualization of chromosome dynamics allows the investigation of spatiotemporal chromatin organization and its role in gene regulation and other cellular processes. However, current approaches to label multiple genomic loci in live cells have a fundamental limitation in the number of loci that can b...

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Detalles Bibliográficos
Autores principales: Takei, Yodai, Shah, Sheel, Harvey, Sho, Qi, Lei S., Cai, Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425380/
https://www.ncbi.nlm.nih.gov/pubmed/28427715
http://dx.doi.org/10.1016/j.bpj.2017.03.024