TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

Aberrant WNT signaling drives colorectal cancer (CRC). Here, we identify TIAM1 as a critical antagonist of CRC progression through inhibiting TAZ and YAP, effectors of WNT signaling. We demonstrate that TIAM1 shuttles between the cytoplasm and nucleus antagonizing TAZ/YAP by distinct mechanisms in t...

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Detalles Bibliográficos
Autores principales: Diamantopoulou, Zoi, White, Gavin, Fadlullah, Muhammad Z.H., Dreger, Marcel, Pickering, Karen, Maltas, Joe, Ashton, Garry, MacLeod, Ruth, Baillie, George S., Kouskoff, Valerie, Lacaud, Georges, Murray, Graeme I., Sansom, Owen J., Hurlstone, Adam F.L., Malliri, Angeliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425402/
https://www.ncbi.nlm.nih.gov/pubmed/28416184
http://dx.doi.org/10.1016/j.ccell.2017.03.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425402/
https://www.ncbi.nlm.nih.gov/pubmed/28416184
http://dx.doi.org/10.1016/j.ccell.2017.03.007

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