Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction

Physiological function and pathology of the Alzheimer’s disease causing amyloid precursor protein (APP) are correlated with its cytosolic adaptor Fe65 encompassing a WW and two phosphotyrosine-binding domains (PTBs). The C-terminal Fe65-PTB2 binds a large portion of the APP intracellular domain (AIC...

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Detalles Bibliográficos
Autores principales: Feilen, Lukas P., Haubrich, Kevin, Strecker, Paul, Probst, Sabine, Eggert, Simone, Stier, Gunter, Sinning, Irmgard, Konietzko, Uwe, Kins, Stefan, Simon, Bernd, Wild, Klemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425604/
https://www.ncbi.nlm.nih.gov/pubmed/28553201
http://dx.doi.org/10.3389/fnmol.2017.00140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425604/
https://www.ncbi.nlm.nih.gov/pubmed/28553201
http://dx.doi.org/10.3389/fnmol.2017.00140

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