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Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction
Physiological function and pathology of the Alzheimer’s disease causing amyloid precursor protein (APP) are correlated with its cytosolic adaptor Fe65 encompassing a WW and two phosphotyrosine-binding domains (PTBs). The C-terminal Fe65-PTB2 binds a large portion of the APP intracellular domain (AIC...
Autores principales: | Feilen, Lukas P., Haubrich, Kevin, Strecker, Paul, Probst, Sabine, Eggert, Simone, Stier, Gunter, Sinning, Irmgard, Konietzko, Uwe, Kins, Stefan, Simon, Bernd, Wild, Klemens |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425604/ https://www.ncbi.nlm.nih.gov/pubmed/28553201 http://dx.doi.org/10.3389/fnmol.2017.00140 |
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