In Vivo RNAi Screen Unveils PPARγ as a Regulator of Hematopoietic Stem Cell Homeostasis

Hematopoietic stem cell (HSC) defects can cause repopulating impairment leading to hematologic diseases. To target HSC deficiency in a disease setting, we exploited the repopulating defect of Fanconi anemia (FA) HSCs to conduct an in vivo short hairpin RNA (shRNA) screen. We exposed Fancd2(−/−) HSCs...

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Detalles Bibliográficos
Autores principales: Sertorio, Mathieu, Du, Wei, Amarachintha, Surya, Wilson, Andrew, Pang, Qishen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425620/
https://www.ncbi.nlm.nih.gov/pubmed/28416286
http://dx.doi.org/10.1016/j.stemcr.2017.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425620/
https://www.ncbi.nlm.nih.gov/pubmed/28416286
http://dx.doi.org/10.1016/j.stemcr.2017.03.008

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