Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays

The ability to form teratomas in vivo containing multiple somatic cell types is regarded as functional evidence of pluripotency for human pluripotent stem cells (hPSCs). Since the Teratoma assay is animal dependent, laborious, and only qualitative, the PluriTest and the hPSC ScoreCard assay have bee...

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Detalles Bibliográficos
Autores principales: Bouma, Marga J., van Iterson, Maarten, Janssen, Bart, Mummery, Christine L., Salvatori, Daniela C.F., Freund, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425621/
https://www.ncbi.nlm.nih.gov/pubmed/28494940
http://dx.doi.org/10.1016/j.stemcr.2017.03.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425621/
https://www.ncbi.nlm.nih.gov/pubmed/28494940
http://dx.doi.org/10.1016/j.stemcr.2017.03.009

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