2i Maintains a Naive Ground State in ESCs through Two Distinct Epigenetic Mechanisms

Mouse embryonic stem cells (ESCs) are maintained in serum with leukemia inhibitory factor (LIF) to maintain self-renewal and pluripotency. Recently, a 2i culture method was reported using a combination of MEK inhibition (MEKi) and GSK3 inhibition (GSK3i) with LIF to maintain ESCs in a naive ground s...

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Detalles Bibliográficos
Autores principales: Sim, Ye-Ji, Kim, Min-Seong, Nayfeh, Abeer, Yun, Ye-Jin, Kim, Su-Jin, Park, Kyung-Tae, Kim, Chang-Hoon, Kim, Kye-Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425728/
https://www.ncbi.nlm.nih.gov/pubmed/28457889
http://dx.doi.org/10.1016/j.stemcr.2017.04.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425728/
https://www.ncbi.nlm.nih.gov/pubmed/28457889
http://dx.doi.org/10.1016/j.stemcr.2017.04.001

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