Impact of food, alcohol and pH on modified-release hydrocortisone developed to treat congenital adrenal hyperplasia

BACKGROUND: We developed a modified-release hydrocortisone, Chronocort, to replace the cortisol rhythm in patients with congenital adrenal hyperplasia. Food, alcohol and pH affect drug absorption, and it is important to assess their impact when replicating a physiological rhythm. SUBJECTS AND METHOD...

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Detalles Bibliográficos
Autores principales: Karunasena, Nayananjani, Margetson, Daniel N, Neal, Greg, Whitaker, Martin J, Ross, Richard JM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2017
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425936/
https://www.ncbi.nlm.nih.gov/pubmed/28100629
http://dx.doi.org/10.1530/EJE-16-0948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425936/
https://www.ncbi.nlm.nih.gov/pubmed/28100629
http://dx.doi.org/10.1530/EJE-16-0948

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