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Interdependence of Inhibitor Recognition in HIV-1 Protease

[Image: see text] Molecular recognition is a highly interdependent process. Subsite couplings within the active site of proteases are most often revealed through conditional amino acid preferences in substrate recognition. However, the potential effect of these couplings on inhibition and thus inhib...

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Detalles Bibliográficos
Autores principales: Paulsen, Janet L., Leidner, Florian, Ragland, Debra A., Kurt Yilmaz, Nese, Schiffer, Celia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425943/
https://www.ncbi.nlm.nih.gov/pubmed/28358514
http://dx.doi.org/10.1021/acs.jctc.6b01262