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Distinct cellular toxicity of two mutant huntingtin mRNA variants due to translation regulation
Huntington’s disease (HD) is a neurodegenerative disorder caused by CAG repeat expansion within exon1 of the HTT gene. The gene generates two mRNA variants that carry either a short or long 3′ untranslated region (3′UTR) while encoding the same protein. It remains unknown whether the two mRNA varian...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426682/ https://www.ncbi.nlm.nih.gov/pubmed/28494017 http://dx.doi.org/10.1371/journal.pone.0177610 |