Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats

Hyperglycemia in diabetes alters tight junction (TJ) proteins in the kidney. We evaluated the participation of aldosterone (ALD), and the effect of spironolactone (SPL), a mineralocorticoid receptor antagonist, on the expressions of claudin-2, -4, -5 and -8, and occludin in glomeruli, proximal and d...

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Detalles Bibliográficos
Autores principales: Molina-Jijón, Eduardo, Rodríguez-Muñoz, Rafael, González-Ramírez, Ricardo, Namorado-Tónix, Carmen, Pedraza-Chaverri, José, Reyes, Jose L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426686/
https://www.ncbi.nlm.nih.gov/pubmed/28493961
http://dx.doi.org/10.1371/journal.pone.0177362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426686/
https://www.ncbi.nlm.nih.gov/pubmed/28493961
http://dx.doi.org/10.1371/journal.pone.0177362

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