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Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats
Hyperglycemia in diabetes alters tight junction (TJ) proteins in the kidney. We evaluated the participation of aldosterone (ALD), and the effect of spironolactone (SPL), a mineralocorticoid receptor antagonist, on the expressions of claudin-2, -4, -5 and -8, and occludin in glomeruli, proximal and d...
Autores principales: | Molina-Jijón, Eduardo, Rodríguez-Muñoz, Rafael, González-Ramírez, Ricardo, Namorado-Tónix, Carmen, Pedraza-Chaverri, José, Reyes, Jose L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426686/ https://www.ncbi.nlm.nih.gov/pubmed/28493961 http://dx.doi.org/10.1371/journal.pone.0177362 |
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