Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells

Breast carcinoma cells use specialized, actin-rich protrusions called invadopodia to degrade and invade through the extracellular matrix. Phosphorylation of the actin nucleation–promoting factor and actin-stabilizing protein cortactin downstream of the epidermal growth factor receptor–Src-Arg kinase...

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Detalles Bibliográficos
Autores principales: Rosenberg, Brian J., Gil-Henn, Hava, Mader, Christopher C., Halo, Tiffany, Yin, Taofei, Condeelis, John, Machida, Kazuya, Wu, Yi I., Koleske, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426849/
https://www.ncbi.nlm.nih.gov/pubmed/28356423
http://dx.doi.org/10.1091/mbc.E16-12-0885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426849/
https://www.ncbi.nlm.nih.gov/pubmed/28356423
http://dx.doi.org/10.1091/mbc.E16-12-0885

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