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The Pharmacogenetics of Tacrolimus in Corticosteroid-Sparse Pediatric and Adult Kidney Transplant Recipients
INTRODUCTION: Tacrolimus is a calcineurin inhibitor used as an immunosuppressant drug in solid organ transplantation, and is mainly metabolized by cytochrome P450 (CYP) 3A4 and CYP3A5. Studies have shown an association between the CYP3A5 genotype and tacrolimus dose-adjusted trough concentrations. V...
Autores principales: | Madsen, Mads Juul, Bergmann, Troels K., Brøsen, Kim, Thiesson, Helle Charlotte |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427048/ https://www.ncbi.nlm.nih.gov/pubmed/28229376 http://dx.doi.org/10.1007/s40268-017-0177-9 |
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