Simple and cost-effective liquid chromatography-mass spectrometry method to measure dabrafenib quantitatively and six metabolites semi-quantitatively in human plasma

Dabrafenib is an inhibitor of BRAF V600E used for treating metastatic melanoma but a majority of patients experience adverse effects. Methods to measure the levels of dabrafenib and major metabolites during treatment are needed to allow development of individualized dosing strategies to reduce the b...

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Detalles Bibliográficos
Autores principales: Vikingsson, Svante, Dahlberg, Jan-Olof, Hansson, Johan, Höiom, Veronica, Gréen, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427163/
https://www.ncbi.nlm.nih.gov/pubmed/28429064
http://dx.doi.org/10.1007/s00216-017-0316-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427163/
https://www.ncbi.nlm.nih.gov/pubmed/28429064
http://dx.doi.org/10.1007/s00216-017-0316-8

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