Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

Human pluripotent stem cells (hPSCs) can self-renew indefinitely, making them an attractive source for regenerative therapies. This expansion potential has been linked with acquisition of large copy number variants (CNVs) that provide mutant cells with a growth advantage in culture1–3. However, the...

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Detalles Bibliográficos
Autores principales: Merkle, Florian T., Ghosh, Sulagna, Kamitaki, Nolan, Mitchell, Jana, Avior, Yishai, Mello, Curtis, Kashin, Seva, Mekhoubad, Shila, Ilic, Dusko, Charlton, Maura, Saphier, Genevieve, Handsaker, Robert E., Genovese, Giulio, Bar, Shiran, Benvenisty, Nissim, McCarroll, Steven A., Eggan, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427175/
https://www.ncbi.nlm.nih.gov/pubmed/28445466
http://dx.doi.org/10.1038/nature22312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427175/
https://www.ncbi.nlm.nih.gov/pubmed/28445466
http://dx.doi.org/10.1038/nature22312

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