Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway

Sirtuin1 (SIRT1) and forkhead box transcription factor O subfamily 1 (FOXO1) play vital roles in the maintenance of hippocampal neuronal homeostasis during aging. Our previous study showed that melatonin, a hormone mainly secreted by the pineal gland, restored the impaired memory of aged mice. Age-r...

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Detalles Bibliográficos
Autores principales: Jenwitheesuk, Anorut, Boontem, Parichart, Wongchitrat, Prapimpun, Tocharus, Jiraporn, Mukda, Sujira, Govitrapong, Piyarat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427465/
https://www.ncbi.nlm.nih.gov/pubmed/28507478
http://dx.doi.org/10.17179/excli2016-852

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427465/
https://www.ncbi.nlm.nih.gov/pubmed/28507478
http://dx.doi.org/10.17179/excli2016-852

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