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Melatonin regulates the aging mouse hippocampal homeostasis via the sirtuin1-FOXO1 pathway
Sirtuin1 (SIRT1) and forkhead box transcription factor O subfamily 1 (FOXO1) play vital roles in the maintenance of hippocampal neuronal homeostasis during aging. Our previous study showed that melatonin, a hormone mainly secreted by the pineal gland, restored the impaired memory of aged mice. Age-r...
Autores principales: | Jenwitheesuk, Anorut, Boontem, Parichart, Wongchitrat, Prapimpun, Tocharus, Jiraporn, Mukda, Sujira, Govitrapong, Piyarat |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Leibniz Research Centre for Working Environment and Human Factors
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427465/ https://www.ncbi.nlm.nih.gov/pubmed/28507478 http://dx.doi.org/10.17179/excli2016-852 |
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