USP9X deubiquitylating enzyme maintains RAPTOR protein levels, mTORC1 signalling and proliferation in neural progenitors

USP9X, is highly expressed in neural progenitors and, essential for neural development in mice. In humans, mutations in USP9X are associated with neurodevelopmental disorders. To understand USP9X’s role in neural progenitors, we studied the effects of altering its expression in both the human neural...

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Detalles Bibliográficos
Autores principales: Bridges, Caitlin R., Tan, Men-Chee, Premarathne, Susitha, Nanayakkara, Devathri, Bellette, Bernadette, Zencak, Dusan, Domingo, Deepti, Gecz, Jozef, Murtaza, Mariyam, Jolly, Lachlan A., Wood, Stephen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427856/
https://www.ncbi.nlm.nih.gov/pubmed/28341829
http://dx.doi.org/10.1038/s41598-017-00149-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427856/
https://www.ncbi.nlm.nih.gov/pubmed/28341829
http://dx.doi.org/10.1038/s41598-017-00149-0

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