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RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFA(xxx)b isoforms

Vascular endothelial growth factor (VEGFA), a pivotal regulator of angiogenesis and valuable therapeutic target, is characterised by alternative splicing which generates three principal isoforms, VEGFA(121), VEGFA(165) and VEGFA(189). A second set of anti-angiogenic isoforms termed VEGFA(xxx)b that...

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Detalles Bibliográficos
Autores principales: Bridgett, Stephen, Dellett, Margaret, Simpson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427905/
https://www.ncbi.nlm.nih.gov/pubmed/28246395
http://dx.doi.org/10.1038/s41598-017-00100-3