hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state

Delayed-rectifier potassium channels (hERG and KCNQ1) play a major role in cardiac repolarization. These channels are formed by a tetrameric pore (S5–S6) surrounded by four voltage sensor domains (S1-S4). Coupling between voltage sensor domains and the pore activation gate is critical for channel vo...

Descripción completa

Detalles Bibliográficos
Autores principales: Malak, Olfat A., Es-Salah-Lamoureux, Zeineb, Loussouarn, Gildas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427910/
https://www.ncbi.nlm.nih.gov/pubmed/28273916
http://dx.doi.org/10.1038/s41598-017-00155-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427910/
https://www.ncbi.nlm.nih.gov/pubmed/28273916
http://dx.doi.org/10.1038/s41598-017-00155-2

Ejemplares similares