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hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state
Delayed-rectifier potassium channels (hERG and KCNQ1) play a major role in cardiac repolarization. These channels are formed by a tetrameric pore (S5–S6) surrounded by four voltage sensor domains (S1-S4). Coupling between voltage sensor domains and the pore activation gate is critical for channel vo...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427910/ https://www.ncbi.nlm.nih.gov/pubmed/28273916 http://dx.doi.org/10.1038/s41598-017-00155-2 |