De novo [PSI(+)] prion formation involves multiple pathways to form infectious oligomers

Prion and other neurodegenerative diseases are associated with misfolded protein assemblies called amyloid. Research has begun to uncover common mechanisms underlying transmission of amyloids, yet how amyloids form in vivo is still unclear. Here, we take advantage of the yeast prion, [PSI (+)], to u...

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Detalles Bibliográficos
Autores principales: Sharma, Jaya, Wisniewski, Brett T., Paulson, Emily, Obaoye, Joanna O., Merrill, Stephen J., Manogaran, Anita L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427932/
https://www.ncbi.nlm.nih.gov/pubmed/28250435
http://dx.doi.org/10.1038/s41598-017-00135-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427932/
https://www.ncbi.nlm.nih.gov/pubmed/28250435
http://dx.doi.org/10.1038/s41598-017-00135-6

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