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Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy

Oxidative stress constitutes a major cause for increased risk of congenital malformations associated to severe hyperglycaemia during pregnancy. Mutations in the gene encoding the transcription factor ALX3 cause congenital craniofacial and neural tube defects. Since oxidative stress and lack of ALX3...

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Detalles Bibliográficos
Autores principales: García-Sanz, Patricia, Mirasierra, Mercedes, Moratalla, Rosario, Vallejo, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428206/
https://www.ncbi.nlm.nih.gov/pubmed/28341857
http://dx.doi.org/10.1038/s41598-017-00334-1