New cofactors and inhibitors for a DNA-cleaving DNAzyme: superoxide anion and hydrogen peroxide mediated an oxidative cleavage process

Herein, we investigated the effects of new cofactors and inhibitors on an oxidative cleavage of DNA catalysis, known as a pistol-like DNAzyme (PLDz), to discuss its catalytic mechanism. PLDz performed its catalytic activity in the presence of ascorbic acid (AA), in which Cu(2+) promoted, whereas Fe(...

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Detalles Bibliográficos
Autores principales: Sun, Yanhong, Ma, Rulong, Wang, Shijin, Li, Guiying, Sheng, Yongjie, Rui, Hongyue, Zhang, Jin, Xu, Jiacui, Jiang, Dazhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428237/
https://www.ncbi.nlm.nih.gov/pubmed/28336968
http://dx.doi.org/10.1038/s41598-017-00329-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428237/
https://www.ncbi.nlm.nih.gov/pubmed/28336968
http://dx.doi.org/10.1038/s41598-017-00329-y

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