Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2

Phosphoenolpyruvate carboxykinase 1 (PEPCK1) is the critical enzyme for gluconeogenesis and is linked with type II diabetes. Previous studies have found that SIRT2, a deacetylase, plays an important role in deacetylating PEPCK1 and little is known about the anti-diabetic activity of SIRT2 inhibitors...

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Detalles Bibliográficos
Autores principales: Zhang, Mingming, Pan, Yida, Dorfman, Robert G., Yin, Yuyao, Zhou, Qian, Huang, Shan, Liu, Jie, Zhao, Shimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428341/
https://www.ncbi.nlm.nih.gov/pubmed/28127057
http://dx.doi.org/10.1038/s41598-017-00035-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428341/
https://www.ncbi.nlm.nih.gov/pubmed/28127057
http://dx.doi.org/10.1038/s41598-017-00035-9

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