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Sirtinol promotes PEPCK1 degradation and inhibits gluconeogenesis by inhibiting deacetylase SIRT2

Phosphoenolpyruvate carboxykinase 1 (PEPCK1) is the critical enzyme for gluconeogenesis and is linked with type II diabetes. Previous studies have found that SIRT2, a deacetylase, plays an important role in deacetylating PEPCK1 and little is known about the anti-diabetic activity of SIRT2 inhibitors...

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Detalles Bibliográficos
Autores principales:	Zhang, Mingming, Pan, Yida, Dorfman, Robert G., Yin, Yuyao, Zhou, Qian, Huang, Shan, Liu, Jie, Zhao, Shimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428341/ https://www.ncbi.nlm.nih.gov/pubmed/28127057 http://dx.doi.org/10.1038/s41598-017-00035-9

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