Altered Metabolic Profiles Associate with Toxicity in SOD1(G93A) Astrocyte-Neuron Co-Cultures

Non-cell autonomous processes involving astrocytes have been shown to contribute to motor neuron degeneration in amyotrophic lateral sclerosis. Mutant superoxide dismutase 1 (SOD1(G93A)) expression in astrocytes is selectively toxic to motor neurons in co-culture, even when mutant protein is express...

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Detalles Bibliográficos
Autores principales: Valbuena, Gabriel N., Tortarolo, Massimo, Bendotti, Caterina, Cantoni, Lavinia, Keun, Hector C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428359/
https://www.ncbi.nlm.nih.gov/pubmed/28246392
http://dx.doi.org/10.1038/s41598-017-00072-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428359/
https://www.ncbi.nlm.nih.gov/pubmed/28246392
http://dx.doi.org/10.1038/s41598-017-00072-4

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