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Altered Metabolic Profiles Associate with Toxicity in SOD1(G93A) Astrocyte-Neuron Co-Cultures
Non-cell autonomous processes involving astrocytes have been shown to contribute to motor neuron degeneration in amyotrophic lateral sclerosis. Mutant superoxide dismutase 1 (SOD1(G93A)) expression in astrocytes is selectively toxic to motor neurons in co-culture, even when mutant protein is express...
Autores principales: | Valbuena, Gabriel N., Tortarolo, Massimo, Bendotti, Caterina, Cantoni, Lavinia, Keun, Hector C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428359/ https://www.ncbi.nlm.nih.gov/pubmed/28246392 http://dx.doi.org/10.1038/s41598-017-00072-4 |
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