Cargando…

Altered Metabolic Profiles Associate with Toxicity in SOD1(G93A) Astrocyte-Neuron Co-Cultures

Non-cell autonomous processes involving astrocytes have been shown to contribute to motor neuron degeneration in amyotrophic lateral sclerosis. Mutant superoxide dismutase 1 (SOD1(G93A)) expression in astrocytes is selectively toxic to motor neurons in co-culture, even when mutant protein is express...

Descripción completa

Detalles Bibliográficos
Autores principales:	Valbuena, Gabriel N., Tortarolo, Massimo, Bendotti, Caterina, Cantoni, Lavinia, Keun, Hector C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428359/ https://www.ncbi.nlm.nih.gov/pubmed/28246392 http://dx.doi.org/10.1038/s41598-017-00072-4

Ejemplares similares

Spinal Cord Metabolic Signatures in Models of Fast- and Slow-Progressing SOD1(G93A) Amyotrophic Lateral Sclerosis
por: Valbuena, Gabriel N., et al.
Publicado: (2019)

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes: IMPLICATIONS FOR DISEASE SPREADING AND MOTOR NEURON PATHOLOGY IN AMYOTROPHIC LATERAL SCLEROSIS
por: Basso, Manuela, et al.
Publicado: (2013)

Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically
por: Paizs, Melinda, et al.
Publicado: (2011)

Metabolomic Analysis Reveals Increased Aerobic Glycolysis and Amino Acid Deficit in a Cellular Model of Amyotrophic Lateral Sclerosis
por: Valbuena, Gabriel N., et al.
Publicado: (2015)

Immune response in peripheral axons delays disease progression in SOD1(G93A) mice
por: Nardo, Giovanni, et al.
Publicado: (2016)

Perturbations of the Proteome and of Secreted Metabolites in Primary Astrocytes from the hSOD1(G93A) ALS Mouse Model
por: Stella, Roberto, et al.
Publicado: (2021)

Counteracting roles of MHCI and CD8(+) T cells in the peripheral and central nervous system of ALS SOD1(G93A) mice
por: Nardo, Giovanni, et al.
Publicado: (2018)

Characterization of somatosensory neuron involvement in the SOD1(G93A) mouse model
por: Rubio, Miguel A., et al.
Publicado: (2022)

P2X7 activation enhances skeletal muscle metabolism and regeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
por: Fabbrizio, Paola, et al.
Publicado: (2019)

Neuronal–glial communication perturbations in murine SOD1(G93A) spinal cord
por: MacLean, Michael, et al.
Publicado: (2022)

Alterations in AQP4 expression and polarization in the course of motor neuron degeneration in SOD1G93A mice
por: Dai, Jiaying, et al.
Publicado: (2017)

Novel P2X7 Antagonist Ameliorates the Early Phase of ALS Disease and Decreases Inflammation and Autophagy in SOD1-G93A Mouse Model
por: Apolloni, Savina, et al.
Publicado: (2021)

SOD1(G93A) Astrocyte-Derived Extracellular Vesicles Induce Motor Neuron Death by a miRNA-155-5p-Mediated Mechanism
por: Marton, Soledad, et al.
Publicado: (2023)

Neuromuscular effects of G93A-SOD1 expression in zebrafish
por: Sakowski, Stacey A, et al.
Publicado: (2012)

Mitochondria-Targeted Catalase Reverts the Neurotoxicity of hSOD1(G93A) Astrocytes without Extending the Survival of ALS-Linked Mutant hSOD1 Mice
por: Pehar, Mariana, et al.
Publicado: (2014)

Trophic and proliferative effects of Shh on motor neurons in embryonic spinal cord culture from wildtype and G93A SOD1 mice
por: Ma, Xiaoxing, et al.
Publicado: (2013)

Scolopendra subspinipes mutilans attenuates neuroinflammation in symptomatic hSOD1(G93A) mice
por: Cai, MuDan, et al.
Publicado: (2013)

Metabolic Changes Associated With Muscle Expression of SOD1(G93A)
por: Dobrowolny, Gabriella, et al.
Publicado: (2018)

Lysosomal and phagocytic activity is increased in astrocytes during disease progression in the SOD1 (G93A) mouse model of amyotrophic lateral sclerosis
por: Baker, David J., et al.
Publicado: (2015)

Tempol Moderately Extends Survival in a hSOD1(G93A) ALS Rat Model by Inhibiting Neuronal Cell Loss, Oxidative Damage and Levels of Non-Native hSOD1(G93A) Forms
por: Linares, Edlaine, et al.
Publicado: (2013)

MPO/HOCl Facilitates Apoptosis and Ferroptosis in the SOD1(G93A) Motor Neuron of Amyotrophic Lateral Sclerosis
por: Peng, Jialing, et al.
Publicado: (2022)

RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue
por: Vallarola, Antonio, et al.
Publicado: (2018)

CIIA prevents SOD1(G93A)-induced cytotoxicity by blocking ASK1-mediated signaling
por: Lee, Jae Keun, et al.
Publicado: (2014)

Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1(G93A) and NSG animal models
por: Izrael, Michal, et al.
Publicado: (2018)

Regional Differences in Heat Shock Protein 25 Expression in Brain and Spinal Cord Astrocytes of Wild-Type and SOD1 (G93A) Mice
por: San Gil, Rebecca, et al.
Publicado: (2021)

A closer look at the SOD1(G93Adl) mouse model of ALS
Publicado: (2011)

Genetic Biomarkers for ALS Disease in Transgenic SOD1(G93A) Mice
por: Calvo, Ana C., et al.
Publicado: (2012)

Microglia Morphological Changes in the Motor Cortex of hSOD1(G93A) Transgenic ALS Mice
por: Migliarini, Sara, et al.
Publicado: (2021)

Influence of Methylene Blue on Microglia-Induced Inflammation and Motor Neuron Degeneration in the SOD1(G93A) Model for ALS
por: Dibaj, Payam, et al.
Publicado: (2012)

Compensatory Motor Neuron Response to Chromatolysis in the Murine hSOD1(G93A) Model of Amyotrophic Lateral Sclerosis
por: Riancho, Javier, et al.
Publicado: (2014)

Overexpression of ferroptosis defense enzyme Gpx4 retards motor neuron disease of SOD1G93A mice
por: Chen, Liuji, et al.
Publicado: (2021)

Modulation of SOD1 Subcellular Localization by Transfection with Wild- or Mutant-type SOD1 in Primary Neuron and Astrocyte Cultures from ALS Mice
por: Lee, Do-Yeon, et al.
Publicado: (2015)

Therapeutic rAAVrh10 Mediated SOD1 Silencing in Adult SOD1(G93A) Mice and Nonhuman Primates
por: Borel, Florie, et al.
Publicado: (2016)

Adaptive Immune Neuroprotection in G93A-SOD1 Amyotrophic Lateral Sclerosis Mice
por: Banerjee, Rebecca, et al.
Publicado: (2008)

Monoaminergic control of spinal locomotor networks in SOD1(G93A) newborn mice
por: Milan, Léa, et al.
Publicado: (2014)

Histamine Is an Inducer of the Heat Shock Response in SOD1-G93A Models of ALS
por: Apolloni, Savina, et al.
Publicado: (2019)

SIRT1 Interacts with Prepro-Orexin in the Hypothalamus in SOD1G93A Mice
por: Zhang, Gan, et al.
Publicado: (2022)

Resveratrol Ameliorates Motor Neuron Degeneration and Improves Survival in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
por: Song, Lin, et al.
Publicado: (2014)

Changes in the Expression of FUS/TLS in Spinal Cords of SOD1 G93A Transgenic Mice and Correlation with Motor-Neuron Degeneration
por: Li, Jiao, et al.
Publicado: (2016)

LncRNAs Associated with Neuronal Development and Oncogenesis Are Deregulated in SOD1-G93A Murine Model of Amyotrophic Lateral Sclerosis
por: Rey, Federica, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1uv4f53s52libi2imuji8fkq4n