Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation

Plasminogen activator inhibitor-1 (PAI-1) is known to protect mice against cardiac fibrosis. It has been speculated that PAI-1 may regulate cardiac fibrosis by inactivating urokinase-type plasminogen activator (uPA) and ultimately plasmin (Pm) generation. However, the in vivo role of PAI-1 in inacti...

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Detalles Bibliográficos
Autores principales: Gupta, Kamlesh K., Donahue, Deborah L., Sandoval-Cooper, Mayra J., Castellino, Francis J., Ploplis, Victoria A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428408/
https://www.ncbi.nlm.nih.gov/pubmed/28336948
http://dx.doi.org/10.1038/s41598-017-00418-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428408/
https://www.ncbi.nlm.nih.gov/pubmed/28336948
http://dx.doi.org/10.1038/s41598-017-00418-y

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