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Apigenin-induced lysosomal degradation of β-catenin in Wnt/β-catenin signaling

The bioflavonoid apigenin has been shown to possess cancer-preventive and anti-cancer activities. In a drug screening, we found that apigenin can inhibit Wnt/β-catenin signaling, a pathway that participates in pivotal biological functions, which dis-regulation results in various human diseases inclu...

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Detalles Bibliográficos
Autores principales: Lin, Chung-Ming, Chen, Hsin-Han, Lin, Chun-An, Wu, Hui-Chung, Sheu, Jim Jinn-Chyuan, Chen, Hui-Jye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428476/
https://www.ncbi.nlm.nih.gov/pubmed/28337019
http://dx.doi.org/10.1038/s41598-017-00409-z