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Exploring Approaches for Detecting Protein Functional Similarity within an Orthology-based Framework

Protein functional similarity based on gene ontology (GO) annotations serves as a powerful tool when comparing proteins on a functional level in applications such as protein-protein interaction prediction, gene prioritization, and disease gene discovery. Functional similarity (FS) is usually quantif...

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Detalles Bibliográficos
Autores principales: Weichenberger, Christian X., Palermo, Antonia, Pramstaller, Peter P., Domingues, Francisco S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428484/
https://www.ncbi.nlm.nih.gov/pubmed/28336965
http://dx.doi.org/10.1038/s41598-017-00465-5