Delivery of ENaC siRNA to epithelial cells mediated by a targeted nanocomplex: a therapeutic strategy for cystic fibrosis

The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function. The challenge has been to deliver siRNA to the lung with sufficient efficacy for a sustained therapeutic...

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Detalles Bibliográficos
Autores principales: Manunta, Maria D. I., Tagalakis, Aristides D., Attwood, Martin, Aldossary, Ahmad M., Barnes, Josephine L., Munye, Mustafa M., Weng, Alexander, McAnulty, Robin J, Hart, Stephen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428798/
https://www.ncbi.nlm.nih.gov/pubmed/28386087
http://dx.doi.org/10.1038/s41598-017-00662-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428798/
https://www.ncbi.nlm.nih.gov/pubmed/28386087
http://dx.doi.org/10.1038/s41598-017-00662-2

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