TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice

Tissue inhibitor of metalloproteinases-1 (TIMP-1) is upregulated during hepatic fibrogenesis and considered to promote fibrosis in the injured liver by inhibition of matrix metalloproteases (MMP) and degradation of extracellular matrix. Moreover, TIMP-1 displays anti-apoptotic properties, in patient...

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Detalles Bibliográficos
Autores principales: Thiele, Nina D., Wirth, Jan W., Steins, David, Koop, Anja C., Ittrich, Harald, Lohse, Ansgar W., Kluwe, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428806/
https://www.ncbi.nlm.nih.gov/pubmed/28386095
http://dx.doi.org/10.1038/s41598-017-00671-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428806/
https://www.ncbi.nlm.nih.gov/pubmed/28386095
http://dx.doi.org/10.1038/s41598-017-00671-1

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