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TIMP-1 is upregulated, but not essential in hepatic fibrogenesis and carcinogenesis in mice

Tissue inhibitor of metalloproteinases-1 (TIMP-1) is upregulated during hepatic fibrogenesis and considered to promote fibrosis in the injured liver by inhibition of matrix metalloproteases (MMP) and degradation of extracellular matrix. Moreover, TIMP-1 displays anti-apoptotic properties, in patient...

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Detalles Bibliográficos
Autores principales:	Thiele, Nina D., Wirth, Jan W., Steins, David, Koop, Anja C., Ittrich, Harald, Lohse, Ansgar W., Kluwe, Johannes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428806/ https://www.ncbi.nlm.nih.gov/pubmed/28386095 http://dx.doi.org/10.1038/s41598-017-00671-1

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