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TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity

Several transient receptor potential (TRP) ion channels can be directly activated by hot or cold temperature with high sensitivity. However, the structures and molecular mechanism giving rise to their high temperature sensitivity are not fully understood. One hypothesized mechanism assumes that temp...

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Detalles Bibliográficos
Autores principales: Sosa-Pagán, Jason O., Iversen, Edwin S., Grandl, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428820/
https://www.ncbi.nlm.nih.gov/pubmed/28373693
http://dx.doi.org/10.1038/s41598-017-00636-4