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Farnesoid X receptor, a novel proto-oncogene in non-small cell lung cancer, promotes tumor growth via directly transactivating CCND1

Farnesoid X receptor (FXR), a nuclear receptor for maintaining bile acid homeostasis, has been recognized as a tumor suppressor in enterohepatic tissues. However, its expression and functional role in non-small cell lung cancer (NSCLC) remain unclear. We report that FXR is significantly increased in...

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Detalles Bibliográficos
Autores principales: You, Wenjie, Chen, Bi, Liu, Xueqing, Xue, Shan, Qin, Hui, Jiang, Handong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428828/
https://www.ncbi.nlm.nih.gov/pubmed/28377627
http://dx.doi.org/10.1038/s41598-017-00698-4