Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice

Alternative splicing of tau exon 10 generates tau isoforms with three or four microtubule-binding repeats, 3R-tau and 4R-tau, which is equally expressed in adult human brain. Imbalanced expression in 3R-tau and 4R-tau has been found in several sporadic and inherited tauopathies, suggesting that dysr...

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Detalles Bibliográficos
Autores principales: Yin, Xiaomin, Jin, Nana, Shi, Jianhua, Zhang, Yanchong, Wu, Yue, Gong, Cheng-Xin, Iqbal, Khalid, Liu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428843/
https://www.ncbi.nlm.nih.gov/pubmed/28377597
http://dx.doi.org/10.1038/s41598-017-00682-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428843/
https://www.ncbi.nlm.nih.gov/pubmed/28377597
http://dx.doi.org/10.1038/s41598-017-00682-y

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