PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz

Dephosphorylation of translation initiation factor 2 (eIF2α) terminates signalling in the mammalian integrated stress response (ISR) and has emerged as a promising target for modifying the course of protein misfolding diseases. The [(o-chlorobenzylidene)amino]guanidines (Guanabenz and Sephin1) have...

Descripción completa

Detalles Bibliográficos
Autores principales: Crespillo-Casado, Ana, Chambers, Joseph E, Fischer, Peter M, Marciniak, Stefan J, Ron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429092/
https://www.ncbi.nlm.nih.gov/pubmed/28447936
http://dx.doi.org/10.7554/eLife.26109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429092/
https://www.ncbi.nlm.nih.gov/pubmed/28447936
http://dx.doi.org/10.7554/eLife.26109

Ejemplares similares