Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ

The DNA methyltransferase Dnmt3a suppresses tumorigenesis in models of leukemia and lung cancer. Conversely, deregulation of Dnmt3b is thought to generally promote tumorigenesis. However, the role of Dnmt3a and Dnmt3b in many types of cancer remains undefined. Here, we show that Dnmt3a and Dnmt3b ar...

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Detalles Bibliográficos
Autores principales: Rinaldi, Lorenzo, Avgustinova, Alexandra, Martín, Mercè, Datta, Debayan, Solanas, Guiomar, Prats, Neus, Benitah, Salvador Aznar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429093/
https://www.ncbi.nlm.nih.gov/pubmed/28425913
http://dx.doi.org/10.7554/eLife.21697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429093/
https://www.ncbi.nlm.nih.gov/pubmed/28425913
http://dx.doi.org/10.7554/eLife.21697

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