Acidic cellular microenvironment modifies carcinogen-induced DNA damage and repair

Chronic inflammation creates an acidic microenvironment, which plays an important role in cancer development. To investigate how low pH changes the cellular response to the carcinogen benzo[a]pyrene (B[a]P), we incubated human pulmonary epithelial cells (A549 and BEAS-2B) with nontoxic doses of B[a]...

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Detalles Bibliográficos
Autores principales: Shi, Q., Maas, L., Veith, C., Van Schooten, F. J., Godschalk, R. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Genotoxicity and Carcinogenicity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429366/
https://www.ncbi.nlm.nih.gov/pubmed/28005143
http://dx.doi.org/10.1007/s00204-016-1907-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429366/
https://www.ncbi.nlm.nih.gov/pubmed/28005143
http://dx.doi.org/10.1007/s00204-016-1907-4

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