Cargando…

The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma

This article focusses on the role of TGF-β and its signaling crosstalk with the RHO family GTPases RAC1 and RAC1b in the progression of breast and pancreatic carcinoma. The aggressive nature of these tumor types is mainly due to metastatic dissemination. Metastasis is facilitated by desmoplasia, a p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Melzer, Catharina, Hass, Ralf, von der Ohe, Juliane, Lehnert, Hendrik, Ungefroren, Hendrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429551/ https://www.ncbi.nlm.nih.gov/pubmed/28499439 http://dx.doi.org/10.1186/s12964-017-0175-0

Ejemplares similares

TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b
por: Melzer, Catharina, et al.
Publicado: (2017)

RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression
por: Melzer, Catharina, et al.
Publicado: (2019)

Changes in uPA, PAI-1, and TGF-β Production during Breast Cancer Cell Interaction with Human Mesenchymal Stroma/Stem-Like Cells (MSC)
por: Melzer, Catharina, et al.
Publicado: (2019)

Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells
por: Melzer, Catharina, et al.
Publicado: (2017)

The Small GTPase RAC1B: A Potent Negative Regulator of-and Useful Tool to Study-TGFβ Signaling
por: Ungefroren, Hendrik, et al.
Publicado: (2020)

RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGFβ1 in the Suppression of Cell Motility
por: Ungefroren, Hendrik, et al.
Publicado: (2020)

RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5
por: Ungefroren, Hendrik, et al.
Publicado: (2019)

Negative regulation of TGF-β1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b
por: Witte, David, et al.
Publicado: (2017)

RAC1B Induces SMAD7 via USP26 to Suppress TGFβ1-Dependent Cell Migration in Mesenchymal-Subtype Carcinoma Cells
por: Ungefroren, Hendrik, et al.
Publicado: (2020)

The Ratio of RAC1B to RAC1 Expression in Breast Cancer Cell Lines as a Determinant of Epithelial/Mesenchymal Differentiation and Migratory Potential
por: Eiden, Caroline, et al.
Publicado: (2021)

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
por: Ungefroren, Hendrik, et al.
Publicado: (2011)

RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5
por: Otterbein, Hannah, et al.
Publicado: (2019)

RAC1B: A Guardian of the Epithelial Phenotype and Protector Against Epithelial-Mesenchymal Transition
por: Zinn, Rabea, et al.
Publicado: (2019)

Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling
por: Ungefroren, Hendrik, et al.
Publicado: (2013)

Potential Role of MSC/Cancer Cell Fusion and EMT for Breast Cancer Stem Cell Formation
por: Hass, Ralf, et al.
Publicado: (2019)

Negative Control of Cell Migration by Rac1b in Highly Metastatic Pancreatic Cancer Cells Is Mediated by Sequential Induction of Nonactivated Smad3 and Biglycan
por: Otterbein, Hannah, et al.
Publicado: (2019)

The Intimate Relationship among EMT, MET and TME: A T(ransdifferentiation) E(nhancing) M(ix) to Be Exploited for Therapeutic Purposes
por: Hass, Ralf, et al.
Publicado: (2020)

Impact of the Tumor Microenvironment on Tumor Heterogeneity and Consequences for Cancer Cell Plasticity and Stemness
por: Hass, Ralf, et al.
Publicado: (2020)

Suppressive Role of ACVR1/ALK2 in Basal and TGFβ1-Induced Cell Migration in Pancreatic Ductal Adenocarcinoma Cells and Identification of a Self-Perpetuating Autoregulatory Loop Involving the Small GTPase RAC1b
por: Ungefroren, Hendrik, et al.
Publicado: (2022)

Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regulation of Stemness Factors
por: Schmidtlein, Paula Marie, et al.
Publicado: (2021)

Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer
por: Ungefroren, Hendrik, et al.
Publicado: (2018)

TGF-β Signaling in Cancer: Control by Negative Regulators and Crosstalk with Proinflammatory and Fibrogenic Pathways
por: Ungefroren, Hendrik
Publicado: (2019)

Characterization of Spontaneous and TGF-β-Induced Cell Motility of Primary Human Normal and Neoplastic Mammary Cells In Vitro Using Novel Real-Time Technology
por: Mandel, Katharina, et al.
Publicado: (2013)

Breast Carcinoma: From Initial Tumor Cell Detachment to Settlement at Secondary Sites
por: Melzer, Catharina, et al.
Publicado: (2017)

Correction: Characterization of Spontaneous and TGF-β-Induced Cell Motility of Primary Human Normal and Neoplastic Mammary Cells In Vitro Using Novel Real-Time Technology
por: Mandel, Katharina, et al.
Publicado: (2013)

In Vivo Cell Fusion between Mesenchymal Stroma/Stem-Like Cells and Breast Cancer Cells
por: Melzer, Catharina, et al.
Publicado: (2019)

Involvement of Actin Cytoskeletal Components in Breast Cancer Cell Fusion with Human Mesenchymal Stroma/Stem-Like Cells
por: Melzer, Catharina, et al.
Publicado: (2019)

Enhanced metastatic capacity of breast cancer cells after interaction and hybrid formation with mesenchymal stroma/stem cells (MSC)
por: Melzer, Catharina, et al.
Publicado: (2018)

Spontaneous Fusion of MSC with Breast Cancer Cells Can Generate Tumor Dormancy
por: Melzer, Catharina, et al.
Publicado: (2021)

Autocrine TGFβ1 Opposes Exogenous TGFβ1-Induced Cell Migration and Growth Arrest through Sustainment of a Feed-Forward Loop Involving MEK-ERK Signaling
por: Ungefroren, Hendrik, et al.
Publicado: (2021)

MSC stimulate ovarian tumor growth during intercellular communication but reduce tumorigenicity after fusion with ovarian cancer cells
por: Melzer, Catharina, et al.
Publicado: (2018)

Anti-Tumor Effects of Exosomes Derived from Drug-Incubated Permanently Growing Human MSC
por: Melzer, Catharina, et al.
Publicado: (2020)

Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC
por: Melzer, Catharina, et al.
Publicado: (2020)

The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility
por: Ungefroren, Hendrik, et al.
Publicado: (2017)

Interaction of tumor cells with the microenvironment
por: Ungefroren, Hendrik, et al.
Publicado: (2011)

Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells
por: Melzer, Catharina, et al.
Publicado: (2019)

Autocrine TGF-β in Cancer: Review of the Literature and Caveats in Experimental Analysis
por: Ungefroren, Hendrik
Publicado: (2021)

Negative regulation of TGFβ-induced apoptosis by RAC1B enhances intestinal tumourigenesis
por: Gudiño, Victoria, et al.
Publicado: (2021)

TGF-β-induced cell motility requires downregulation of ARHGAPs to sustain Rac1 activity
por: Motizuki, Mitsuyoshi, et al.
Publicado: (2021)

Crosstalk between Aldosterone and Glycation through Rac-1 Induces Diabetic Nephropathy
por: Apte, Mayura, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nmrblhbdsj8bvo8c2728fuoe2l