Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory

BACKGROUND: The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection against Mycobacterium tuberculosis (Mtb) infection. METHODS: Applying spatial epid...

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Autores principales: Bosch, Lander, Bosch, Barbara, De Boeck, Kris, Nawrot, Tim, Meyts, Isabelle, Vanneste, Dominique, Le Bourlegat, Cleonice Alexandre, Croda, Julio, da Silva Filho, Luiz Vicente Ribeiro Ferreira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429554/
https://www.ncbi.nlm.nih.gov/pubmed/28499359
http://dx.doi.org/10.1186/s12879-017-2448-z
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author Bosch, Lander
Bosch, Barbara
De Boeck, Kris
Nawrot, Tim
Meyts, Isabelle
Vanneste, Dominique
Le Bourlegat, Cleonice Alexandre
Croda, Julio
da Silva Filho, Luiz Vicente Ribeiro Ferreira
author_facet Bosch, Lander
Bosch, Barbara
De Boeck, Kris
Nawrot, Tim
Meyts, Isabelle
Vanneste, Dominique
Le Bourlegat, Cleonice Alexandre
Croda, Julio
da Silva Filho, Luiz Vicente Ribeiro Ferreira
author_sort Bosch, Lander
collection PubMed
description BACKGROUND: The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection against Mycobacterium tuberculosis (Mtb) infection. METHODS: Applying spatial epidemiology, we studied the link between CF carriership rate and tuberculosis (TB) incidence in Brazil. We corrected for 5 potential environmental and 2 immunological confounders in this relation: monthly income, sanitary provisions, literacy rates, racial composition and population density along with AIDS incidence rates and diabetes mellitus type 2. Smoking data were incomplete and not available for analysis. RESULTS: A significant, negative correlation between CF carriership rate and TB incidence, independent of any of the seven confounders was found. CONCLUSION: We provide exploratory support for the hypothesis that carrying a single CFTR mutation arms against Mtb infections.
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spelling pubmed-54295542017-05-15 Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory Bosch, Lander Bosch, Barbara De Boeck, Kris Nawrot, Tim Meyts, Isabelle Vanneste, Dominique Le Bourlegat, Cleonice Alexandre Croda, Julio da Silva Filho, Luiz Vicente Ribeiro Ferreira BMC Infect Dis Research Article BACKGROUND: The reason why Cystic Fibrosis (CF) is the most common fatal genetic disease among Caucasians has been incompletely studied. We aimed at deepening the hypothesis that CF carriers have a relative protection against Mycobacterium tuberculosis (Mtb) infection. METHODS: Applying spatial epidemiology, we studied the link between CF carriership rate and tuberculosis (TB) incidence in Brazil. We corrected for 5 potential environmental and 2 immunological confounders in this relation: monthly income, sanitary provisions, literacy rates, racial composition and population density along with AIDS incidence rates and diabetes mellitus type 2. Smoking data were incomplete and not available for analysis. RESULTS: A significant, negative correlation between CF carriership rate and TB incidence, independent of any of the seven confounders was found. CONCLUSION: We provide exploratory support for the hypothesis that carrying a single CFTR mutation arms against Mtb infections. BioMed Central 2017-05-12 /pmc/articles/PMC5429554/ /pubmed/28499359 http://dx.doi.org/10.1186/s12879-017-2448-z Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Bosch, Lander
Bosch, Barbara
De Boeck, Kris
Nawrot, Tim
Meyts, Isabelle
Vanneste, Dominique
Le Bourlegat, Cleonice Alexandre
Croda, Julio
da Silva Filho, Luiz Vicente Ribeiro Ferreira
Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory
title Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory
title_full Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory
title_fullStr Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory
title_full_unstemmed Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory
title_short Cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the Brazilian territory
title_sort cystic fibrosis carriership and tuberculosis: hints toward an evolutionary selective advantage based on data from the brazilian territory
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429554/
https://www.ncbi.nlm.nih.gov/pubmed/28499359
http://dx.doi.org/10.1186/s12879-017-2448-z
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