The dynamics of early-state transcriptional changes and aggregate formation in a Huntington’s disease cell model

BACKGROUND: Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by a CAG expansion in the Huntingtin (HTT) gene. Proteolytic cleavage of mutant huntingtin (Htt) protein with an expanded polyglutamine (polyQ) stretch results in production of Htt fragments that aggregate and induce...

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Detalles Bibliográficos
Autores principales: van Hagen, Martijn, Piebes, Diewertje G. E., de Leeuw, Wim C., Vuist, Ilona M., van Roon-Mom, Willeke M. C., Moerland, Perry D., Verschure, Pernette J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429582/
https://www.ncbi.nlm.nih.gov/pubmed/28499347
http://dx.doi.org/10.1186/s12864-017-3745-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429582/
https://www.ncbi.nlm.nih.gov/pubmed/28499347
http://dx.doi.org/10.1186/s12864-017-3745-z

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